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KMID : 1155520120070040312
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Anesthesia and Pain Medicine
2012 Volume.7 No. 4 p.312 ~ p.316
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Comparison of palonosetron with ondansetron in preventing postoperative nausea and vomiting after thyroidectomy during a 48-hour period
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Kim Yu-Yil
Song Dong-Un
Lee Ki-Hyun
Lee Il-Jung
Song Jae-Wook
Lim Jin-Hun
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Abstract
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Background:Postoperative nausea and vomiting (PONV) are common complications after general anesthesia. This study compared the effects of palonosetron and ondansetron in preventing PONV in patients undergoing thyroidectomy. Methods:100 non-smoking female subjects were randomly assigned to a palonosetron group (n = 50) or an ondansetron group (n = 50). The patients of each group received 0.075 mg of palonosetron or 8 mg of ondansetron through intravenous bolus injection before induction of general anesthesia. The incidence of nausea and vomiting were monitored at 2 h, 24 h and 48 h after operation. Results:The incidence of PONV during 48 h after operation had no significant differences between the groups. However, the incidence of nausea was lower in the palonosetron group than in the ondansetron group (34% vs. 56%, P = 0.027). No differences were observed in incidences of vomiting, use of antiemetics and adverse events between the groups. Conclusions:Palonosetron was more effective than ondansetron in preventing nausea for patients undergoing thyroidectomy. However, the effect of palonosetron or ondansetron in preventing PONV was similar. (Anesth Pain Med 2012; 7: 312∼316)
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KEYWORD
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Ondansetron, Palonosetron, Postoperative nausea and vomiting (PONV), Thyroidectomy
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